- Review Article
- Efficacy and effectiveness of extended-valency pneumococcal conjugate vaccines
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Hyunju Lee, Eun Hwa Choi, Hoan Jong Lee
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Clin Exp Pediatr. 2014;57(2):55-66. Published online February 24, 2014
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The 7-valent pneumococcal protein conjugate vaccine (PCV7) has been shown to be highly efficacious against invasive pneumococcal diseases and effective against pneumonia and in reducing otitis media. The introduction of PCV7 has resulted in major changes in the epidemiology of pneumococcal diseases. However, pneumococcal vaccines induce serotype-specific immunity, and a relative increase in non-vaccine serotypes has been reported following the... |
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- Recommendation for the use of newly introduced Tdap vaccine in Korea
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Kyong Min Choi, Kyung Hyo Kim, Yae-Jean Kim, Jong-Hyun Kim, Su Eun Park, Hoan Jong Lee, Byung Wook Eun, Dae Sun Jo, Eun Hwa Choi, Young Jin Hong
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Clin Exp Pediatr. 2011;54(4):141-145. Published online April 30, 2011
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Pertussis is an acute respiratory infection characterized by paroxysmal cough and inspiratory whoop for over 2 weeks. The incidence of pertussis has decreased markedly after the introduction of DTwP/DTaP vaccine, but the incidence of pertussis has increased steadily among young infant and among adolescents and adults in many countries. Td vaccine was used in this age group but the increase... |
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- Recommendation for use of the newly introduced pneumococcal protein conjugate vaccines in Korea
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Eun Hwa Choi, Kyung Hyo Kim, Yae Jean Kim, Jong Hyun Kim, Su Eun Park, Hoan Jong Lee, Byung Wook Eun, Dae Sun Jo, Kyong Min Choi, Young Jin Hong
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Clin Exp Pediatr. 2011;54(4):146-151. Published online April 30, 2011
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Streptococcus pneumoniae remains a leading cause of invasive infections including bacteremia and meningitis, as well as mucosal infections such as otitis media and pneumonia among children and adults. The 7-valent pneumococcal conjugate vaccine (PCV7) was licensed for use among infants and young children in many countries including Korea. The routine use of PCV7 has resulted in a decreased incidence of... |
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- Original Article
- Detection of genetic mutations associated with macrolide resistance of Mycoplasma pneumoniae
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Chi Eun Oh, Eun Hwa Choi, Hoan Jong Lee
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Clin Exp Pediatr. 2010;53(2):178-183. Published online February 15, 2010
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Purpose : The aim of this study was to identify mutations associated with macrolide resistance in Mycoplasma pneumoniae (MP) and to establish a cultural method to determine antimicrobial susceptibility.
Methods : Nasopharyngeal aspirates (NPAs) were collected from 62 children diagnosed with MP pneumonia by a serologic method or polymerase chain reaction. The 23S rRNA and L4 ribosomal protein genes of MP... |
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- Therapeutic monitoring of vancomycin according to initial dosing regimen in pediatric patients
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Dae Il Kim, Mi Sun Im, Jin Hyoung Choi, Jina Lee, Eun Hwa Choi, Hoan Jong Lee
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Clin Exp Pediatr. 2010;53(12):1000-1005. Published online December 31, 2010
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Purpose This study aimed to determine the optimal initial vancomycin dose to achieve appropriate trough levels in pediatric patients. MethodsWe analyzed clinical data for 309 children treated with intravenous vancomycin between 2004 and 2009 at 2 different hospitals in South Korea. The patients were 1-16 years old and exhibited normal renal function. Patient data, including reason for treatment and initial dosing regimen,... |
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- Review Article
- Novel swine-origin H1N1 influenza
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Jina Lee, Hoan Jong Lee
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Clin Exp Pediatr. 2009;52(8):862-868. Published online August 15, 2009
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Since its identification in April 2009, a swine-origin H1N1 influenza A virus (S-OIV) which is a reassortment of gene segments
from both North American triple-reassortant and Eurasian swine influenza has been widely spread among humans in unexpected
rapidity. To date, each gene segment of the 2009 influenza A (H1N1) outbreak viruses have shown high (99.9%) neucleotide
sequence identity. As of July 6, 94,512... |
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- Original Article
- Association between Kawasaki disease and acute respiratory viral infections
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Eun Young Cho, Byung Wook Eun, Nam Hee Kim, Jina Lee, Eun Hwa Choi, Hoan Jong Lee, Jung Yun Choi
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Clin Exp Pediatr. 2009;52(11):1241-1248. Published online November 15, 2009
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Purpose : The etiology of Kawasaki disease (KD) is still unknown. Recently, an association between human coronavirus NL63 (HCoV-NL63) and KD was implicated. Hence, we attempted to determine the association between KD and acute respiratory viral infections.
Methods : Nasopharyngeal aspirate samples were obtained from 54 patients diagnosed with KD at the Seoul National University (SNU) Children’s Hospital and SNU-Bundang Hospital... |
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- Erratum
- Provisional update on varicella vaccination in Korea, 2008
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Eun Hwa Choi, Kyung Hyo Kim, Jong-Hyun Kim, Su Eun Park, Seon Hee Shin, Sung Hee Oh, Hoan Jong Lee, Dae Sun Jo, Jae Kyun Hur, Young Jin Hong
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Clin Exp Pediatr. 2008;51(6):665-667. Published online June 15, 2008
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- Original Article
- Clinical characteristics of severe respiratory syncytial virus infection
requiring mechanical ventilation in neonatal period and early infancy
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Seung Han Shin, Jae Ri Kim, Jin-A Lee, Chang Won Choi, Ee-Kyung Kim, Eun Hwa Choi, Han-Suk Kim, Beyong Il Kim, Hoan Jong Lee, Jung-Hwan Choi
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Clin Exp Pediatr. 2008;51(4):372-376. Published online April 15, 2008
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Purpose : To identify clinical characteristics of severe respiratory syncytial virus (RSV) in neonatal period and early infancy and provide information in clinical practice.
Methods : Twelve neonates and young infants (<6 months) who were infected by respiratory syncytial virus and required mechanical ventilation between March 2005 and July 2007 were enrolled. Diagnosis of RSV infection was made based on the... |
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- Erratum
- Rotavirus Vaccine
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Su Eun Park, Kyung Hyo Kim, Jong-Hyun Kim, Seon Hee Shin, Sung Hee Oh, Hoan Jong Lee, Dae Sun Jo, Eun Hwa Choi, Jae Kyun Hur, Young Jin Hong
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Clin Exp Pediatr. 2007;50(8):803-810. Published online August 15, 2007
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- Human Papillomavirus Vaccine
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Kyung Hyo Kim, Jong-Hyun Kim, Su Eun Park, Seon Hee Shin, Sung Hee Oh, Hoan Jong Lee, Dae Sun Jo, Eun Hwa Choi, Jae Kyun Hur, Young Jin Hong
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Clin Exp Pediatr. 2007;50(8):811-819. Published online August 15, 2007
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- Original Article
- Antibody prsistence after Haemophilus influenzae type b (Hib)
primary vaccination and response to boosters in Korean children
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Hyunju Lee, So Eun Park, Soo Young Lim, Kyong Min Choi, Hoan Jong Lee, Kyung Hyo Kim
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Clin Exp Pediatr. 2007;50(5):449-456. Published online May 15, 2007
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Purpose : Antibody persistence after primary series of Haemophilus influenzae type b (Hib) vaccine and responses to boosters are seldom studied in Korean children. We performed this study to evaluate the antibody titer in relation to booster immunization of Hib vaccine in Korean children.
Method : One hundred forty four children aged 12-23 months were enrolled in three university hospitals. The... |
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- A study of serotyping of Streptococcus pneumoniae by multibead assay
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Ky Young Cho, Jung Ah Lee, Sung Eun Cho, Nam Hee Kim, Jin A Lee, Ki Sook Hong, Hoan Jong Lee, Kyung Hyo Kim
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Clin Exp Pediatr. 2007;50(2):151-156. Published online February 15, 2007
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Purpose : Streptococcus pneumoniae is a major etiologic agent for pneumonia, meningitis, otitis media, and sepsis among young children. Multi-drug resistant strains have raised great concern worldwide, thus the importance of prevention with vaccines has been emphasized. However, vaccines may force the appearance of pneumococcal infections by nonvaccine serotypes. Thus, distribution of pneumococcal serotypes should be monitored to estimate vaccine... |
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- Review Article
- Efficacy and effectiveness of pneumococcal conjugate vaccine in children
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Hoan Jong Lee
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Clin Exp Pediatr. 2006;49(3):235-241. Published online March 15, 2006
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Streptococus pneumoniae is an important cause of invasive infections as well as non-invasive infections such as acute otitis media and sinusitis both in children and adults. Resistance of S. pneumoniae to multiple antimicrobials is increasing and poses therapeutic challenges, and prevention became more important. 23-valent polysaccharide vaccine has been used for the last several decades, but is not effective in... |
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- Original Article
- Difference in the Transcriptional Activity of the Interleukin-4 Promoter Haplotypes
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Eun Hwa Choi, Hee Sup Kim, Stephen J. Chanock, Hoan Jong Lee
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Clin Exp Pediatr. 2005;48(5):495-499. Published online May 15, 2005
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Purpose : Interleukin-4(IL-4) is a critical component of the Th2 cytokine pathway and contributes to severity of respiratory syncytial virus(RSV) bronchiolitis. Previous studies observed an association between severe RSV bronchiolitis in Korean children with a common haplotype of the IL4 promoter. This study was performed to investigate functional differences of the variant IL4 promoter haplotypes.
Methods : Genomic DNA was obtained... |
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- Clinical Entities and Etiology of Invasive Bacterial Infections in Apparently Healthy Children
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Joon Ho Lee, Eun Kyoung Song, Jin A Lee, Nam Hee Kim, Dong Ho Kim, Ki Won Park, Eun Hwa Choi, Hoan Jong Lee
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Clin Exp Pediatr. 2005;48(11):1193-1200. Published online November 15, 2005
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ilus influenzae has been declined to 4% each from 23% and 14%, respectively, compared to previous study. S. agalactiae was the most common isolate in the infants ≤3 months. Among the infants and children aged 3 months to 2 years and children of 2-5 years, S. pneumoniae(57%, 52%, respectively, in each group) was the most common isolates followed by S.... |
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- Risk Factors of Urinary Tract Infections Due to Extended-spectrum β-lactamase Producing Escherichia coli in Children
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Nam Hee Kim, Jin A Lee, Yun Kyung Kim, Eun Hwa Choi, Il Soo Ha, Hoan Jong Lee, Yong Choi
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Clin Exp Pediatr. 2004;47(2):164-169. Published online February 15, 2004
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Purpose : This study was performed to identify risk factors for urinary tract infection(UTI) by extended-spectrum β-lactamase(ESBL)-producing Escherichia coli in children.
Methods : We analyzed 125 episodes of UTI which were developed in 112 children at the Seoul National University Children's Hospital from July to December 2002. Medical records of 74 episodes of UTI caused by E. coli were reviewed in... |
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- Prevalence of Antibodies against Adenoviruses in Korean Children and Adults
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Hyun Oh Jang, Jin A Lee, Nam Hee Kim, Eun Hee Chung, Hoan Jong Lee
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Clin Exp Pediatr. 2004;47(12):1300-1305. Published online December 15, 2004
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Purpose : Adenoviruses(Ads) are responsible for approximately 10 percent of lower respiratory tract infections(LRTIs) in children. The purpose of this study is to evaluate the prevalence of antibodies (Abs) against common serotypes of Ads in Korean children and adults.
Methods : The sera were tested for neutralizing Abs against Ad serotypes 1 through 7 and 21 with a colorimetric microneutralization assay... |
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- A Questionnaire on Using Informed Consents of Parents or Guardians in Vaccination of Children
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Seung-Hi Paik, Eun Hee Chung, Mie Ryung Uhm, Son Moon Shin, Woo Gill Lee, Mi Na Lee, Hoan Jong Lee
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Clin Exp Pediatr. 2003;46(7):647-654. Published online July 15, 2003
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Purpose : This study was done to evaluate the parents' or guardians' compliance of obtaining individual informed consent before vaccination and the possible problems of using informed consent.
Methods : One hundred and twelve children were randomly selected among 2,820 children who visited Samsung Cheil Hospital during July 2002. A questionnaire about using informed consent of vaccination was given to all... |
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- Urinary Tract Infections in Febrile Infants under Three Months of Age
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Byung Wook Eun, Yoo Mi Chung, Hee Gyung Kang, Il Soo Ha, Hae Il Cheong, Hoan Jong Lee, Yong Choi
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Clin Exp Pediatr. 2003;46(3):265-270. Published online March 15, 2003
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Purpose : To characterize the infants under 3 months of age with urinary tract infections(UTIs), and especially patients with bacteremia or meningitis
Methods : Hospital records of all the infants under 3 months of age discharged from our hospital for 69 consecutive months with the diagnosis of initial episode of UTI were reviewed. UTI was defined when patients had fever with... |
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- Therapeutic Efficacy of Cefotaxime as an Empirical
Antibiotic on Ascending Cholangitis after
Kasai Operation for Biliary Atresia
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Dong Ho Kim, Byong Sop Lee, Yun Kyung Kim, Jae Sung Ko, Hoan Jong Lee, Jeong Kee Seo
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Clin Exp Pediatr. 2002;45(4):474-481. Published online April 15, 2002
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Purpose : Ascending cholangitis is the most common complication after Kasai operations. The aim of this study is to evaluate the therapeutic efficacy of cefotaxime as an empirical antibiotic on ascending cholangitis after Kasai operations.
Methods : Thirty-nine episodes of cholangitis in twenty-nine children who underwent Kasai operations at Seoul National University Children's Hospital from January 1991 to December 2000 were... |
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- Case Report
- An Infant with Vertical Transmission of Human Immunodeficiency Virus Infection Detected Due to Failure to Thrive
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Byung Wook Eun, Ho Kyung Lim, Yun Kyung Kim, Yuong Ho Kwak, Jung Youn Hong, He Sun Jung, Kyung Mo Kim, Hoan Jong Lee
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Clin Exp Pediatr. 2001;44(5):592-596. Published online May 15, 2001
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Five to fifteen percent of patients affected by human immunodeficiency virus(HIV) are children in developing countries. In Korea, most of HIV infections in children have been transfusion-related, and cases of vertical transmission have been very rare so far and are usually suspected due to a maternal positive history. We experienced a case of vertical transmission of HIV in a 19... |
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- Erratum
- Distribution of Anti-Mumps IgM Antibody in Children Presumptively Diagnosed of Mumps
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Sung Hee Oh, Do Hack Yum, Jin Han Kang, Young Mo Sohn, Hoan Jong Lee, Bok Yang Pyun, Young Jin Hong, Chang Hwi Kim
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Clin Exp Pediatr. 2001;44(1):17-25. Published online January 15, 2001
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Purpose : Outbreaks of mumps continue to occur, even though the number of patients diagnosed of mumps has decreased considerably with the widespread use of vaccine. The accurate diagnosis of mumps is needed to understand the epidemiology of mumps and analyse the safety and effectiveness of vaccine. Therefore, we attempted to appraise the accuracy of provisional diagnosis of mumps in... |
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- Original Article
- Etiologic Agents and Clinical Features of Acute Pyogenic Osteoarthritis in Children
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Young Ho Kwak, Su Eun Park, Jung Youn Hong, He Sun Jung, Jin Young Park, Jung Hwan Choi, Hoan Jong Lee, In Ho Choi
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Clin Exp Pediatr. 2000;43(4):506-513. Published online April 15, 2000
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Purpose : Though acute pyogenic infections of musculoskeletal system are infrequent in children, delayed diagnosis or inadequate management may cause serious chronic sequelae. We analysed 40 cases of children who were affected by acute septic osteomyelitis and/or septic arthritis to find etiologic agents and to establish proper initial antimicrobial therapy.
Methods : Medical records of 40 cases of microbiologically confirmed acute... |
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- Infective Endocarditis in Children : Review of 35 Cases over 11 Years(1987-1997)
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Jeong Jin Yu, Young Ho Kwak, Jung-Youn Hong, He Sun Jung, Jin Young Song, Hoan Jong Lee, Chung Il Noh, Jung Yun Choi, Yong Soo Yun
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Clin Exp Pediatr. 2000;43(4):526-534. Published online April 15, 2000
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Purpose : Infective endocarditis(IE) is a serious complication in children with structural heart disease. We reviewed 35 cases of IE to identify the recent changes in the pattern of preexisting heart diseases, the spectrum of causative organisms and prognosis.
Methods : The clinical records of children diagnosed as IE at the Seoul National University Children`s Hospital from January 1987 through December... |
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- Antibody Response and Adverse Reaction Following Immunization with MMR Vaccine Produced on Human Diploid Cells in Korean Children
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Sung Hee Oh, Jin Han Kang, Young Mo Sohn, Hoan Jong Lee, Bok Yang Pyun, Chang Hwi Kim
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Clin Exp Pediatr. 2000;43(4):489-495. Published online April 15, 2000
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Purpose : This prospective study was performed to evaluate the immunogenecity and safety of MMR vaccine(Triviraten Berna￠c) in Korea children.
Methods : Seventy-three infants aged between 12 to 18 months were recruited from several university hospitals between December 1995 to June 1996. MMR vaccine(Triviraten Berna￠c) was administrered and blood was obtained before and 6-10 weeks after vaccination. IgG antibodies against measles,... |
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- Immunogenicity of Haemophilus influenzae PRP-D Conjugate Vaccine in Korean Infants
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Soo Young Choi, Hee Taek Kim, Yeon Woo Kim, Yun Jong Kang, Yeon Chung Chung, Jin Keun Chang, Hoan Jong Lee
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Clin Exp Pediatr. 1999;42(6):771-777. Published online June 15, 1999
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Purpose : Infection by Haemophilus influenzae Type B(Hib) occurs most often in infants and children who are 5 years old and less. The incidence is highest around 6 months of age, and then decreases thereafter as infants gain natural immunity. Hi PRP-D conjugate vaccine is poorly immunogenic in infants. However, immunogenicity PRP-D vaccine in Korean infants is unknown. This... |
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- The Effect of Measles Vaccination Before Turning 1 Year-old on the Measles Antibody Response to Immunization with MMR
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Soo Jung Choi, Young Jae Koh, Young Mo Soh, Hoan Jong Lee, Sung Hee Oh
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Clin Exp Pediatr. 1998;41(7):909-916. Published online July 15, 1998
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Purpose : With the implementation of measles vaccination programs, the number of patients with measles has decreased. However, epidemics still occur with high morbidity in infants less than 1 year of age. This fact calls for the establishment of optimal preventive measures against measles. The study was carried out to determine the effect of measles vaccination on an infant immunized... |
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- Diagnosis of Bordetella Pertussis Infections by Polymerase Chain Reaction
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Mi Ran Kim, Hee Jung Kang, Hoan Jong Lee
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Clin Exp Pediatr. 1996;39(9):1260-1270. Published online September 15, 1996
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Purpose : Pertussis, a respiratory tract infection caused by Bordetella pertussis, is an important
cause of morbidity in children. But diagnosis of pertussis is often delayed because of late
development of typical symptoms and difficulties in culture. There has been no bacteriologically
confirmed case of B. pertussis infection in Korea. Lower respiratoy tract may be involved in
pertussis. We performed the polymerase chain reaction(PCR)... |
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- Mucormycosis in Leukemic Children
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Seung Ghon Nam, Eun Wha Choi, Jin Young Park, Jong Jae Kim, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn
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Clin Exp Pediatr. 1996;39(3):379-388. Published online March 15, 1996
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Purpose : Mucormycosis is an opportunistic fungal infection caused by one of the ubiquitous fungi of the order Mucorales, occurring almost exclusively in immunocompromised hosts such as patients with diabetes, leukemia and lymphoma. Recently the incidence of mucormycosis is rising associated with the increasing predisposing factors such as cytotoxic drugs and immunosuppressive agents. Though mucormycosis is frequently fatal, there has... |
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- Etiology and Clinical Features of Acute Viral Lower Respiratory Tract Infection in Apparently Healthy children
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Song Yi Nah, Jeong Yun Hong, Eun Hwa Choi, Hoan Jong Lee
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Clin Exp Pediatr. 1996;39(12):1690-1699. Published online December 15, 1996
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Purpose : Acute lower respiratory tract infections(LRIs) are an important cause of pediatric
morbidity and mortality. Causes of acute LRI in infants and children include bacteria,
mycoplasma and respiratory viruses. Understanding of the epidemiology, etiology and clinical
features of acute viral LRI is essential to improve the methods of prevention, diagnosis and
management of these infections.
Methods : Viral etiologic agents and clinical features of... |
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- The Diagnostic Value of Liver Biopsy in Children with Fever of
Unknown Origin and Hepatosplenomegaly
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Sue Mee Park, Yeon Ho Choi, Jong Jae Kim, Hoan Jong Lee, Jeong Kee Seo
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Clin Exp Pediatr. 1996;39(11):1544-1555. Published online November 15, 1996
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Purpose : Although many strides have been made in the radiological and laboratory diagnosis,
the liver biopsy is still considered an important tool for the diagnosis of liver disease. We report
our experience that histologic investigation of the liver was essential searching for the etiologic
diagnosis in eight children with fever of unknowm origin and hepatosplenomegaly, who's
diagnosis were not documented by other diagnostic... |
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- Original Article
- Report of Nationwide Epidemiology of Aseptic Meningitis Outbreak in 1993 in Korea
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Sung Hee Oh, Moo-Song Lee, Jin Han Kang, Chang Hwi Kim, Chong Young Park, Young Mo Sohn, Hoan Jong Lee, Chung Sik Chun, Sang Mann Shin
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Clin Exp Pediatr. 1996;39(1):42-52. Published online January 15, 1996
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Purpose : There has been no nationwide report pertaining to the epidemiology of aseptic meningitis, although a great numer of patients have been diagnosed of the illness. Therefore, we report an explosive outbreak of aseptic meningitis occured in a nationwide scale in 1993.
Methods : Aseptic meningitis epidemiology surveillence was performed retrospectively on the patients diagnosed of aseptic meinigitis from January... |
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- Epidemiology and Vaccine Efficacy of Measles During the 1993 measles Epidemic
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Soon Ki Kim, Jong Woon Choi, Byong Kwan Son, Seung Nam Park, Churl Young Chung, Young Min Ahn, Chong Young Park, Ki Yang Ryoo, Woo Kap Chung, Hoan Jong Lee
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Clin Exp Pediatr. 1995;38(6):778-785. Published online June 15, 1995
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Purpose : Because of increased measles incidence in Korea during 1993 and the recent finding of genomic differences between vaccine virus and contemporary wild measles viruses, we conducted a measles vaccine efficacy study involving children ages 1 to 5 yeark, with the demographic analysis of patients brought to the hospitals during measles outbreak that had occurred 1993 in Seoul and... |
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- Infections in Children with Neoplastic Disease
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Eun Hwa Choi, Jin Won Pyo, Jin Young Park, Kyung Bae Kwon, Bo Young Yun, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn
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Clin Exp Pediatr. 1995;38(3):366-377. Published online March 15, 1995
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Purpose : Infection is a major complication in patients with malignant disease. This study was performed to identify the causes and the etiologic agents of febrile infections and to characterize the clinical courses including the response to antimicrobial agents inpediatric cancer patients.
Methods : This study reviewed 274 febrile episodes occurring in 163 children with neoplastic disease which were indentified prospectively... |
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- Acute Hemorrhagic Cystitis(AHC) in Children -Etiology and Clinical Characteristics-
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Jin Won Pyo, Eun Hwa Choi, Jin Young Park, Hoan Jong Lee, Hae Il Cheong, Il Soo Ha, Yong Choi, Kwang Myung Kim, Hwang Choi, Je Geun Chi
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Clin Exp Pediatr. 1995;38(2):207-215. Published online February 15, 1995
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Purpose : AHC characterized by sudden onset of gross hematuria, dysuria and frequency oc curs in children and young adults as a self-limited disease that should be differentiated from se rious renal disorders. We have performed this study to establish the cause and characterize the clinical features of this illness in Korean children.
Methods : 19 cases collected prospectively for 30... |
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- Clinical Study on Chronic Granulomatous Disease (CGD) -Occurrence in Siblings-
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Yong Hoon Jun, Sung Won Yang, Dong Wook Kim, Hoan Jong Lee, Joong Gon Kim
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Clin Exp Pediatr. 1994;37(6):794-803. Published online June 15, 1994
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To analyse the age of onset, etiologic microorgnisms, clinical manifestations, managements and genetic variation of chronic granulomatous disease, the authors reviewed four patients who were diagnosed as CGD at Department of Pediatrics, Seoul National Univesity Children's Hospital. They were siblings in relationship-two of them were brothers, the others wete brother-sister.
The results were as follows; 1) Initial manifestations developed within 1... |
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- Primary Cutaneous Aspergillosis in Leukemic Children
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Jin Young Park, Mee Ran Kim, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn, Je Guen Chi
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Clin Exp Pediatr. 1994;37(4):520-526. Published online April 15, 1994
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Primary cutaneous aspergillosis is rare. In this report we describe primary skin infection by Aspergillus in 9 children with leukemia. The skin lesion was characterized clinically by erythematous macule and papule associated with pain and itching, followed by a rapid progression to ulcer and central black eschars with raised erythematous border at the site of venipuncture, insertion of intravenous cannula,... |
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- Pharmacokinetics of Gentamicin and Amikacin in Korean Children with Normal Renal Function
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Jin Young Park, Ktung Bae Kwon, Mee Ran Kim, Hoan Jong Lee, Jin Q Kim, Wan Gyoon Shim, Kyoung Ho Park, Hae Lim Chung
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Clin Exp Pediatr. 1994;37(2):185-192. Published online February 15, 1994
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We analysed retrospectively pharmacokinetic parameters of gentamicin and amikacin in 44 and 58 Korean pediatric patients, respectively, with normal renal function. Pharmacokinetic parameters were calculated from two concentrations in serum by method of Sawchuck. There was wide individual variation in peak serum concentrations of gentamicin and amikacin. Administration of the usually recommended doses yielded subtherapeutic concentration in 47% and 82%,... |
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- The Significance of Bacteriologic Examination in the Childhood Tuberculosis
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Kyung Bae Kwon, Jin Young Park, Bo Young Yoon, Mee Ran Kim, Hoan Jong Lee, Eui Jong Kim, Sang Jae Kim
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Clin Exp Pediatr. 1994;37(2):221-230. Published online February 15, 1994
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We reviewed retrospectively the medical records of 229 cases of tuberculosis, who had been diagnosed clinically and admitted to the department of pediatrics, Seoul National University Children's Hospital, during the period of 6 years from October, 1985, to October, 1991.
Patients with tuberculosis occupied 1.2%. of the hospitalized patients. Forty-three percent of the patients were under 3 years of age. Principal... |
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- Case Report
- Candida Esophagitis in Infancy-A Report of 3 Cases
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Ho Sung Kim, Youn Woo Kim, Jae Geon Sim, Beom Soo Park, Hoan Jong Lee, Joong Gon Kim, Jeong Kee Seo, Je Geun Chi
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Clin Exp Pediatr. 1994;37(2):269-275. Published online February 15, 1994
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We experienced 3 cases of Candida esophagitis in infancy which were diagnosed by esophageal endoscopy, First case, 10 month-old boy with combined immune deficiency had suffered from oral thrush and poor feeding for more than 4 months. Esophageal endoscopy revealed multiple whitish creamy patches on the friable erythematous and necrotic mucosa of the esophagus, He was firstly treated with amphotericin-B... |
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- Original Article
- A Clinical Study of Serologically Diagnosed Yersinia Pseudotuberculosis Infection in Children
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Mi Won Kim, Youn Jeong Jeong, Yong Kyu Lee, Jeong Wan Seo, Jin Keun Chang, Hoan Jong Lee
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Clin Exp Pediatr. 1994;37(1):26-32. Published online January 15, 1994
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A retrospective analysis of clinical findings in 23 patients with Y. pseudotuberculosis infection who visited Department of Pediatrics of Han Il Hospital from May, 1990 to June, 1992 was performed.
1)The most prevalent age group was 7 to 12 years (16 case:69.6) and male-to-female ratio was 1.1:1.
2) Monthly distribution showed a high frequency in April, May and June(22 cases:95.8%)
3)The common symptoms... |
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- Case Report
- Recurrent Rhinocerebral Mucormycosis - A Case Report
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Ho Sung Kim, Jin Young Park, Bo Young Yun, Eun Sil Dong, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn, Je Geun Chi, Myung Whun Sung
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Clin Exp Pediatr. 1993;36(4):589-595. Published online April 15, 1993
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A case of recurrent rhinocerebral mucormycosis that has occurred during an induction chemotherapy for acute megakaryocytic leukemia in a 10 year-old boy is reported. He had suffered from high fever, proptosis, right eye ball pain and necrotic inflammation of hard palate during the chemotherapy of leukemia. CT scan of the paranasal sinus showed inflammatory change of right ethmoid and maxillary... |
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- Transfusion-Acquired Cytomegalovirus Infections in Two Premature Infants
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Dong Wook Kim, Kyung Un No, Mi Jung Kim, Soon Mee Park, Hee Sup Kim, Young Pyo Chang, Hoan Jong Lee, Jung-Hwan Choi, Chong Ku Yun, Je Geun Chi
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Clin Exp Pediatr. 1992;35(8):1141-1147. Published online August 15, 1992
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Transfusion-acquired perinatal cytomegalovirus (CMV) infection can cause significant morbidity and mortality, particularly in premature infants with a birth wight of less than 1,500 gm. This recognizable syndrome consisted of deterioration of respiratory function, hepatosplenogaly, unusual gray pallor with disturbing septic appearance, lymphocytosis, thrombocytopenia and hemolytic anemia.
We experienced transfusion-acquired CMV infections in 2 premature infants with a birth weight of... |
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- Original Article
- Cytomegalovirus Infection in Children: The Significance of CMV Specific IgM Antibody Test and Virus Isolation in the Urine
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Dong Wook Kim, Hyun Kwack, Seong Hee Jang, I Seok Kang, Hoan Jong Lee, Jung-Hwan Choi, Jeong Kee Seo, Chong Ku Yun
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Clin Exp Pediatr. 1992;35(7):890-901. Published online July 15, 1992
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The clinical pictures of 44 children with IgM antibody to CMV (cytomegalovirus) by ELISA(enzyme linked immunosorbent assay) were reviewed retrospectively, and the significance of serum CMV specific IgM antibody and virus isolation in the urine was analyzed.
Age of the patients with IgM antibody to CMV ranged from 23 days to 8 years 7 months, and median age was 2 months.... |
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- Septicemia in Children with Neoplastic Disease
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Bo Young Yun, Hoan Jong Lee
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Clin Exp Pediatr. 1992;35(11):1481-1492. Published online November 15, 1992
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This study reviewed 66 episodes of septicemia occurring in 56 children with neoplastic disease at Seoul National University Children뭩 hospital over 31 month period. The most frequent organisms causing 45 episodes in neutropenic patient were Escherichia coli (28%), Klebsiella species (18%), Pseudomonas species (9%), polymicrobic (9%,), and Staphylococcus aureus (7%). The overal mortality was 13% (5/39). The most frequent organisms... |
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- Plasma Somatomedin C Levels in Normal Children
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Bo Young Yun, Hoan Jong Lee
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Clin Exp Pediatr. 1992;35(11):1493-1500. Published online November 15, 1992
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Somatomedin C, the insulin-like growth factor I is suggested to mediate the growth-promoting effect of growth hormone. Sm-C, mostly bound to plasma protein forming an IGF-I protein complex, is slowly cleared from plasma and thus its plasma concentration is quite constant. A single sampling of blood for Sm-C is sufficient for the measurement of its concentration. For the evaluation of... |
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- Clinical and Epidemiologic Features of Respiratory Syncytial Virus Infection
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Hoan Jong Lee, Seong Hee Jang
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Clin Exp Pediatr. 1992;35(10):1389-1401. Published online October 15, 1992
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Although lower respiratory tract infection is a major cause of childhood morbidity in Korea and respiratory viruses are presumed to be important pathogens, there have been few studies available. We diagnosed RSV infection by virus isolation and immunofluorescence in children with lower respiratory tract infection, seen at Seoul National University Children's Hospital from Nov. 1990 to Jul. 1991.
The results were... |
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- Case Report
- Three Cases of Listeria Infection in the Immunocompromised Children
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Mee Ran Kim, Bo Young Yun, Hye Young Kang, Sung Hee Jang, Hoan Jong Lee, Yong Seung Hwang, Eui Chong Kim
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Clin Exp Pediatr. 1992;35(10):1419-1426. Published online October 15, 1992
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Infection by Listeria monocytogenes, an uncommon pathogen in immunocompromised host, has been reported in neonates, pregnant women and adults with defective cell mediated immunity but not in children in Korea. It can cause sepsis, meningitis, abortion, premature labor, intrauterine fetal infection. etc. We have experienced L. monocytogenes sepsis and/or meningitis in three children under immunosuppresive therapy for lymphoma-leukemia, cytophagic histiocytic... |
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- Original Article
- Acute pyogenic arthritis of hip in neonate and infant.
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Mi Jung Kim, Young Ah Lee, Young Pyo Chang, Hoan Jong Lee, Jung Hwan Choi, Chong Ku Yun, Hak Jin Min, In Ho Choi
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Clin Exp Pediatr. 1991;34(2):197-205. Published online February 28, 1991
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Acute pyogenic arthritis of hip is a serious infection that can lead to truly devastating complica-
tions especially in neonatal period and infancy. Clinical survey on twelve neonates and infants (14 hip
joints) with acute pyogenic arthritis of hip who were admitted to the Departments of Pediatrics and
Orthopedic Surgery, Seoul National University Hospital from Jan. 1980 to Dec. 1989 were done.
The results... |
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- Clinical Study of Mycoplasma Pneumoniae Infection in Children.
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Jong Woon Choi, Hoan Jong Lee, Byung Kiu Park, Hyung Ro Moon
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Clin Exp Pediatr. 1990;33(3):315-323. Published online March 31, 1990
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A retrospective analysis of clinical findings in 43 patients with M. pneumoniae infection who visited
Department of Pediatrics of Seoul National University Hospital from January, 1987 till December,
1987 was performed.
1) The peak incidence of age was 5 to 9 years of age (20 cases; 46.5%), and male-to-female ratio was
1.05:1.
2) Monthly distribution showed a high frequency in April (10 cases; 23.3%) and seasonal distribution
showed... |
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- A Clinical Study of Staphylococcus Aureus Infection in Children.
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Yong Joon Shin, Young Pyo Chang, Dong Kyu Jin, Byung Kiu Park, Hoan Jong Lee, Hyung Ro Moon
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Clin Exp Pediatr. 1990;33(1):35-41. Published online January 31, 1990
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We reviewed 113 patients with Staphylococcus aureus infection and 219 strains of Staphylococcus
aureus isolated from pediatric patients of Seoul National University Hospital from Jan. 1, 1987 to
Dec. 31, 1987.
The results were as follows:
1) The proportion of MSSA was 50.2% of total Staphylococcus aureus isolated and that of MRSA
was 49.8%. Staphylococcus aureus were isolated from pus (33.8%), urine (16.9%), ear discharge (8.
2%),... |
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- Infections in Childhood Leukemia.
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Choong Won Lee, Young Sik Kim, Byung Kyu Park, Soon Ki Kim, Il Soo Ha, Hoan Jong Lee, Hyo Seop Ahn
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Clin Exp Pediatr. 1989;32(5):659-664. Published online May 31, 1989
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A retrospective study was performed on twenty-nine children, who had experienced infection one
or more times, among the thirty-eight children diagnosed as leukemia at the Department of
Pediatrics, Seoul National University Hospital, between January, 1984 and June, 1985, and followed
up for more than three years.
The results were as follows;
1) The age of patients ranged from I year 5 months to 14 years... |
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- Three Cases of Typhlitis during Treatment for Acute Myelocytic Leukemia in Children.
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Soon Mee Park, Il Soo Ha, Hoan Jong Lee, Jeong Kee Seo, Hyo Seop Ahn, Kyung Mo Yeon
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Clin Exp Pediatr. 1989;32(10):1455-1462. Published online October 31, 1989
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Typhlitis is a rare necrotizing colitis in which inflammation is confined to cecum. It occurs during
chemotherapy for malignancies, in terminal stage of aplastic anemia, in transplant patients. The
pathogenesis of typhlitis has included leukemic infiltration of the bowel, thrombocytopenia, direct
toxic effects of chemotherapy, steroid, bacterial invasion of the bowel wall secondary to neutropenia
and alteration of the bowel flora by broad-spectrum antibiotics.... |
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- A Clinical Observation on Infective Endocarditis in Childhood.
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Kyung Ae Yoon, Hoan Jong Lee, Young Yull Koh, Jung Yun Choi, Yong Soo Yun, Chang Yee Hong
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Clin Exp Pediatr. 1989;32(1):11-19. Published online January 31, 1989
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Fifty.Six cases with infective endocarditis who were admitted to Department of Pediatrics, Seoul
National University Hospital from January 1979 to December 1986 were reviewed.
All the cases were confirmed bγ clinical findings, blood culture and echocardiographic findings.
The incidence of infective endocarditis was 0.25/ 1,000 admissions. Male to female ratio was 1.2:1. All
the cases had heart defect that was congenital heart disease in... |
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- A Clinical Observation on the Incidence of Childhood Leukemia.
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Hyo Seop Ahn, Il Soo Ha, Soon Ki Kim, Hoan Jong Lee, Chang Yee Hong
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Clin Exp Pediatr. 1988;31(7):841-849. Published online July 31, 1988
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We have analysed the type, age, sex, initial hematologic values and cell markers in 295 children,
who had been diagnosed as leukemia at the department of pediatrics, Seoul National University
Hospital, from Jan. 1983 to Dec. 1987.
The patients were composed of 197 cases (66.8%) of ALL, 82 cases (27.7%) of ANLL and 16 cases
(5.5%) of CML. FAB subclassification have been done in... |
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- Serum C-Reactive Protein in Differential Diagnosis of Meningitis in Children.
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Hae Lim Chung, Hoan Jong Lee, Yong Seung Hwang
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Clin Exp Pediatr. 1988;31(12):1588-1593. Published online December 31, 1988
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CSF findings such as cell count, differential count, protein, glucose and serum CRP determined by
capillary precipitin method evaluated in 90 patients of meningitis admitted to the pediatric ward of
Seoul National University Children’s Hospital, in terms of differential diagnosis of meningitis.
The results are as follows;
1) There was considerable overlap of CSF findings and hematQlogic values between bacterial,
aseptic and tuberculous meningitis groups.
2) All 9... |
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- Two Cases of Tsutsugamushi Disease in Children.
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Eun Saing Jee, Hae Lim Chung, Hoan Jong Lee, Hyung Ro Moon
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Clin Exp Pediatr. 1988;31(11):1509-1515. Published online November 30, 1988
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Tsutsugamushi disease is an acute infectious and febrile disease that is transmitted to human by
larvae of several species of mites, Leptotrimbidium pallidum, Leptotrimbidium akamushi and
Leptotrimbidium scutellare.
Recently in Korea, this disease is increasingly reported in adult age but few cases are reported in
pediatric age.
We experienced two cases of tsutsugamushi disease in children, one of whom had no rash.
This disease should be... |
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- A Clinical Observation on Systemic Lupus Erythematosus in Children.
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Han Wook Yoo, Hae Il Cheong, Hoan Jong Lee, Yong Choi, Kwang Wook Ko, Yong Il Kim
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Clin Exp Pediatr. 1987;30(5):527-535. Published online May 31, 1987
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To elucidate the clinical characteristics of childhood onset systemic lupus erythematosus (SLE), we
carried out a retrospective review on medical records of sixteen patients who were diagnosed as SLE
on the base of “the 1982 revised criteria for the SLE” (by American Rheumatism Association) at the
Department of Pediatrics, Seoul National University Children’s Hospital between January 1976 and July 1986.
The results were summarized... |
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- A Clinical Observation on Fulminant Hepatitis in Children.
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Hoan Jong Lee, Jeong Kee Seo, Hyung Ro Moon
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Clin Exp Pediatr. 1987;30(4):406-415. Published online April 30, 1987
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Twenty-seven cases of fulminant hepatitis in children were retrospectively analyzed. The overall
survival rate was 11%. The interval between onset of encephalopathy and death, and that between
jaundice and death were 2-26 days (median 4 days), 4-61 days (median 14 days), respectively.
HBs antigenemia was detected in 24%, HAV IgM was negative in 5 patients tested, and 4 cases
were suspected as non-A, non-B... |
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- Clinical Observations on Neonatal Sepsis.
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Beyong Il Kim, Hae Lim Chung, Yoon Deok Kim, Weon Soon Park, Son Moon Shin, Hoan Jong Lee, Jung Hwan Choi, Chong Ku Yun
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Clin Exp Pediatr. 1987;30(2):130-138. Published online February 28, 1987
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We studied the 73 cases of proven neonatal sepsis among 11,102 newborn infant under 1 month of
age, admitted to the pediatric ward, the nursery and the NICU of Seoul National University Hospital
from Jan. 1, 1980, to Dec. 31, 1985.
The results were as follows:
1) The incidence was 6.6/1000 live births. Incidence of male babies was 8.3/1000 live births. The
morbidity rate of... |
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- Herpes Zoster in Children.
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Soon Ki Kim, Hoan Jong Lee, Hyo Seop Ahn
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Clin Exp Pediatr. 1986;29(12):1324-1333. Published online December 31, 1986
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Herpes zoster, an inflammatory human disease caused by varicella-zoster virus, is characterized by papulovesicular lesions along the distribution of a sensory nerve. Herpes zoster infection, known to be benign in normal children, is more frequent and severe in immunosuppressed patients and is associated primarily with increased morbidity rather than mortality. We analysed retrospectively the clinical manifestations of herpes zoster infections... |
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- Clinico-pathologic Study Glumerulonephritis with Crescents in 25% or more of Glomeruli in Children.
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Hoan Jong Lee, Kwang Wook Ko
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Clin Exp Pediatr. 1985;28(4):353-371. Published online April 30, 1985
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We experienced 17 pediatric patients of glomerulonephritis with crescents in 25% or more of glomeruli, who were admitted to Department of Pediatrics, Seoul National University Hospital, from Jan. ’79 to Dec. ’84. A review of clinical and pathologic findings revealed as follows; 1)The 17 patients were 10 cases of Henoch-Schdnlein nephritis, 3 cases of idiopathic nephrotic syndrome which were due... |
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- Primary Immunode Ficiency Disorders in Infancy and Childhood.
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Hoan Jong Lee, Jung han Choi, Jeong Kee Seo, Hyo Sup Ahn, Kwang Wook Ko
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Clin Exp Pediatr. 1985;28(3):263-282. Published online March 31, 1985
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The immunodeficiency disorders are a diverse group of illness which results from defectsin one or more of the four major mechanisms of immune system-antibody-mediated(B cell) immunity, cell-mediated(T cell) immunity, phagocytosis, and complements. Though immunodeficiency disorders are uncommon, the possibility should be considered in any individuals with recurrent or persistent infection. During the period between January, 1973 and October, 1984, we... |
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- Captopril in Children with Renovacular Hypertension.
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Yong Choi, Hoan Jong Lee, Hee Young Shin, Kwang Wook Ko, Chang Yee Hong
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Clin Exp Pediatr. 1985;28(1):58-67. Published online January 31, 1985
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Captopril, a kind of converting enzyme inhibitors, is a promising anti-hypertensive drug, which is developed recently, and studied mainly in adult patients. We administered captopril to 4 children with renovascular hypertension, three of them accompanied Takayasu's arteritis and the remainder had isolated lesion. Three to five times of initial trials were performed on each patient with 12.5 mg of captopril.... |
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- Clinical Significance of Selectivity Index in Nephrotic Syndrome.
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Hoan Jong Lee, Hee Jin Kim, Yong Choi, Kwang Wook Ko
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Clin Exp Pediatr. 1984;27(1):68-73. Published online January 31, 1984
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Slectivity I nd ices (CIgG/Ctransf erri n) of 114 nephrotic children, who were admitted to the Pediatric ward of SNUH from January, 1979 to December 1982, were, analyzed in relation to pathology, response to steroid treatment and the variability in the individual patients. In Summary 1)83% of MPGN, and 74% of FSGS showed S.I of more than 0.2 while 36%... |
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